|
KMID : 0376219800170020463
|
|
Chonnam Medical Journal
1980 Volume.17 No. 2 p.463 ~ p.469
|
|
|
Alternation of serum T₃ value in 40 cases of liver cirrhosis
|
|
|
|
|
Abstract
|
|
|
The liver has been recognized as an important site in the peripheral metabolism of thyroid hormones, particularly in the monodeiodination of thyroxine to triiodothyronine. So, for patients with hepatic cirrhosis, levels of thyroid hormones appeared to be indicative of liver dysfunction.
We studied serum concentrations of thyroid hormones and thyrotropin(TSH) in 40 clinically euthyroid patients with hepatic cirrhosis, comparing with conventional liver function tests.
The following results were obtained;
1) The mean serum T3 value, 71±40 ng %, was significantly reduced and the mean serum free T4 value, 1.92±0.77ng%, was significantly higher in patients with hepatic cirrhosis than in the normal subjects(p<0.025). While the mean serum T4 value (8.1±1.33,ug%) and TSH value(4.4±3.1,aU/sae) was similar for the two groups.
2) Patients with low serum T3 levels(less than 80 ng %) had significantly reduced serum T4 value(7.58±0.84,ug%) and higher free T4 value(2.28±0.69 ng %) than patients with normal serum T3 levels(80-220 ng %), but there was no difference in serum TSH value for the two groups.
3) Patients with low serum T3 levels had significant alternations in serum albumin, prothrombin time, bilirubin and alkaline phosphatase with little difference in SGOT and SGPT.
4) In correlation analysis between thyroid function and liver function tests, the serum T3, T4 and free T4 values except TSH value were significantly correlated with serum albumin, prothrombin time, bilirubin and alkaline phosphatase values. There was no correlation between thyroid function tests and level of SGOT and SGPT.
Above results suggested us that levels of thyroid hormones, especially reduced level of serum T3 value was indicative of liver dysfunction in the patients with hepatic cirrhosis.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|